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Barshop Institute for Longevity and Aging Studies

James P. Chambers, Ph.D.


James P. Chambers, Ph.D.

Professor of Biochemistry
Department of Biology
University of Texas at San Antonio
Phone: 210-458-5477


Regulation of intracellular free calcium and its maintenance at extremely low concentrations (submicromolar) is one of the main tasks of cells. Transient calcium fluxes induce the activation of calcium-dependent second messenger systems. Thus, extrusion of excess calcium is critical to the well-being of the cell. Bulk amounts of calcium are removed from the cell cytosol by a Na+/Ca2+ exchanger. In contrast, removal of threshold amounts of free calcium is dependent upon a low capacity, high affinity plasma membrane calcium pump that couples Ca2+ translocation with ATP hydrolysis. We are interested in the characterization of calcium binding proteins in the cell and in particular the kinetic analysis of the [Ca2+ + MG 2+] - dependent adenosine-triphosphatase.

Selected Publications

Jupelli, M., Selby, D.M., Guentzel, M.N., Chambers, J.P., Forsthuber, T.G., Zhong, G., Murthy, A.K. and Arulanandam, B.P.The Contribution of Il-12/IFN-γ Axis in Protection Against Neonatal Pulmonary Chlamydia muridarum Challenge Journal of Interferon and Cytokine Research, 30(6): 407-415, 2010.

Yu, J.J., Goluguri, T.R., Guentzel, M.N., Forsthuber, T.G., Chambers, J.P., Murthy, A.K., Klose, K.E., and Arulanandam B.P.Francisella tularensis T Cell Antigen Identification Using Humanized HLA-DR4 Transgenic Mice Clinical & Vaccine Immunology, 17: 215-222, 2010.

Chaganty, B.K.R., Murthy, A.K., Evani, S.J., Li., W., Guentzel, M.N., Chambers, J.P., Zhong, G., Arulanandam, B.P.Heat Denatured Enzymatically Inactive Recombinant Chlamydial Protease-like Activity Factor Induces Robust Protective Immunity Against Genital Chlamydial ChallengeVaccine, 28: 2323-2329, 2010.

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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

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