Aging is associated with reduction of bone mass, quality and strength leading to bone fragility and an increased risk of fractures and results in an impaired mobility and lowers quality of life. Aging-associated up-regulation of inflammation and oxidative damages are considered to be the key regulatory factors in age-associated bone destruction. Long chain fatty acids, particularly omega-3 fatty acids and conjugated linoleic acids and histone deacetylase inhibitors are anti-inflammatory and anti-oxidative in nature. We are trying to determine the possibility of using these long chain fatty acids and histone deacetylase inhibitors as a preventive and therapeutic approach against osteoporosis and underlying cellular and molecular mechanisms. We are also trying to determine the role of LOX and NOX into the development of osteoporosis and the possibility of using LOX and NOX inhibitors in preventing age-associated bone loss. There are many indications that sarcopenia (muscle loss) coexists with osteopenia (bone loss). The bones and muscles act as two parts of the same functional unit of the musculoskeletal system. Both bone density and muscle strength should be improved to prevent falls and fracture in the elderly. Therefore, the other focus of our research is to determine the signaling crosstalk between muscle and bone and to develop a strategy to maintain both muscle and bone health during aging.
Arunabh Bhattacharya; Ryan Hamilton; Amanda Jernigan; Yiqiang Zhang; Marian Sabia; Md. M. Rahman; Yan Li; Rochelle Wei; Asish Chaudhuri; Holly Van Remmen Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy Free Radical Biology and Medicine. 2014;67:30-40.
Md. Mizanur Rahman; Gabriel Fernandes; Paul Williams Conjugated linoleic acid prevents ovariectomy-induced bone loss in mice by modulating both osteoclastogenesis and osteoblastogenesis Lipids. 2014;49(3):211-224.
Cecilia A. Hinojosa; Ramya Akula Suresh Babu; Md M. Rahman; Gabriel Fernandes; Angela R. Boyd; Carlos J. Orihuela Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs Experimental Gerontology. 2014;54:58-66.