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Barshop Institute for Longevity and Aging Studies

Md Mizanur Rahman, PhD

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Md Mizanur Rahman, PhD

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Assistant Professor/Research
Department of Medicine - Clinical Immunology & Rheumatology
University of Texas Health Science Center at San Antonio
Office: 210-567-3190
RESEARCH INTERESTS: Aging is associated with reduction of bone mass, quality and strength leading to bone fragility and an increased risk of fractures and results in an impaired mobility and lowers quality of life. Aging-associated up-regulation of inflammation and oxidative damages are considered to be the key regulatory factors in age-associated bone destruction. Long chain fatty acids, particularly omega-3 fatty acids and conjugated linoleic acids and histone deacetylase inhibitors are anti-inflammatory and anti-oxidative in nature. We are trying to determine the possibility of using these long chain fatty acids and histone deacetylase inhibitors as a preventive and therapeutic approach against osteoporosis and underlying cellular and molecular mechanisms. We are also trying to determine the role of LOX and NOX into the development of osteoporosis and the possibility of using LOX and NOX inhibitors in preventing age-associated bone loss. There are many indications that sarcopenia (muscle loss) coexists with osteopenia (bone loss). The bones and muscles act as two parts of the same functional unit of the musculoskeletal system. Both bone density and muscle strength should be improved to prevent falls and fracture in the elderly. Therefore, the other focus of our research is to determine the signaling crosstalk between muscle and bone and to develop a strategy to maintain both muscle and bone health during aging.

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The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110
Contact: barshopinstitute@uthscsa.edu
Updated: 6/22/2011
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